Hardwick is the son of professional bowler Billy Hardwick (1941–2013) and Sharon Hills (née Facente), a real estate agent in Pasadena, California.
and he made regular appearances on The Late Late Show with Craig Ferguson and Chelsea Lately.
Between May 2013 and July 2016, he voiced "Craig the Snake" on Sanjay and Craig.
He also voiced the character Vaughn in Telltale Games's Tales from the Borderlands.
In each game, the featured contestant, or "Picker", would eliminate undesired dates using six categories ranging from the innocuous (height, weight) to the blatantly sexual ("Bedroom Behavior", "Package").
Once eight or fewer remained, the Picker would start asking them -style questions, having them perform certain tasks, or both.
He was also the host of @midnight with Chris Hardwick, a nightly comedy-game show series on Comedy Central until it ended its run on August 4, 2017.In 2013, Hardwick hosted Talking Bad, a live half-hour talk show on AMC following the final eight episodes of Breaking Bad, and in 2016 he started to host Talking Saul for Breaking Bads spin-off, Better Call Saul.He is also known for performing with Mike Phirman in Hard 'n Phirm, hosting Singled Out, Wired Science, Web Soup, and Nerdist Podcast, and as the voice of Otis in Back at the Barnyard, replacing Kevin James.Hardwick originated the role of Stacee Jaxx in Rock of Ages during its premiere run in Los Angeles (2005–2006).In 2011, he began hosting Ministry of Laughs, a BBC America Britcom block, and Talking Dead, a live hour talk show on AMC following episodes of The Walking Dead and Fear the Walking Dead.