Synthetic cannabinoids, like the ones found in Marinol, also fit the receptor sites but don’t work as efficiently as the natural ones.
This research barely created a stir when first published as the whole world was still wrapped up in drug war madness.
Ralph Mechoulam who also identified THC as the main active ingredient in cannabis in the early 1960s.
Israel has been one of the most progressive nations for cannabis research and currently has one of the most advanced medical marijuana programs in the world.
Not enough research has been done on the other ones, cannabinol (CBN) and cannabigerol (CBG) plus others, to know much about their mechanisms of effect.
The benefits of CBD-rich medicine, with its anti-spasmodic qualities, is one the most exciting and promising areas of cannabis medical research currently happening.The CB2 receptors are keyed to CBD and works as an anti-inflammatory agent.The immune-boosting functions of CB2 are far less understood as research into CBD is just really beginning.Additionally, CB1 receptors are not present in the part of the brain that regulates heart rate and respiration, so unlike narcotics, there is no lethal dosage threshold for THC, allowing someone to consume as much is needed for its palliative effects.CB2 receptors are primarily found in the immune system with the highest concentration located in the spleen.