Lahn's own calculations acknowledge that the microcephalin variant could have arisen anywhere from 14,000 to 60,000 years ago, and that the uncertainty about the ASPM variant ranged from 500 to 14,000 years ago.
Those criticisms are particularly important, Collins said, because Lahn's testing did find geographic differences in populations harboring the gene variants today.
Aside from not knowing what the gene variants actually do, no one knows how precise the model Lahn used to date them is, Collins added.
They were less common in sub-Saharan African populations, for example.
That does not mean one population is smarter than another, Lahn and other scientists stressed, noting that numerous other genes are key to brain development.
Using DNA samples from ethnically diverse populations, they identified a collection of variations in each gene that occurred with unusually high frequency.
In fact, the variations were so common they couldn't be accidental mutations but instead were probably due to natural selection, where genetic changes that are favorable to a species quickly gain a foothold and begin to spread, the researchers report.